CREAL. Centre de Recerca en Epidemiologia Ambiental


Portada > Cercador de publicacions

TornarCercador de publicacions

de Batlle, J., Sauleda, J., Balcells, E., Gomez, F. P., Mendez, M., Rodriguez, E., Barreiro, E., Ferrer, J. J., Romieu, I., Gea, J., Anto, J. M., Garcia-Aymerich, J.

Association between Omega3 and Omega6 fatty acid intakes and serum inflammatory markers in COPD

J.Nutr.Biochem., 2011, IF: 4.538, PMID: 21889886

Dietary intake of polyunsaturated fatty acids, including omega-3 and omega-6, could modulate chronic obstructive pulmonary disease (COPD) persistent inflammation. We aimed to assess the relationship between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD. A total of 250 clinically stable COPD patients were included. Dietary data of the last 2 years were assessed using a validated food frequency questionnaire (122 items), which provided levels of three omega-3 fatty acids: docosahexaenoic acid, eicosapentaenoic acid and alpha-linolenic acid (ALA); and two omega-6 fatty acids: linoleic acid and arachidonic acid (AA). Inflammatory markers [C-reactive protein (CRP), interleukin (IL)-6, IL-8 and tumor necrosis factor alpha (TNFalpha)] were measured in serum. Fatty acids and inflammatory markers were dichotomised according to their median values, and their association was assessed using multivariate logistic regression. Higher intake of ALA (an anti-inflammatory omega-3 fatty acid) was associated with lower TNFalpha concentrations [adjusted odds ratio (OR)=0.46; P=.049]. Higher AA intake (a proinflammatory omega-6 fatty acid) was related to higher IL-6 (OR=1.96; P=.034) and CRP (OR=1.95; P=.039) concentrations. Therefore, this study provides the first evidence of an association between dietary intake of omega-3 and omega-6 fatty acids and serum inflammatory markers in COPD patients


Imatge ilustrativa

ISGlobal - Campus Mar · Doctor Aiguader, 88 · E-08003 Barcelona · Tel +34 93 214 73 00 · Fax +34 93 214 73 02 · e-mail: RSS

Una iniciativa de:

  • Obra social de la Caixa

  • Hospital Clínic
  • Parc de salut mar
  • Universitat de Barcelona
  • Universitat Pompeu Fabra
  • Generalitat de Catalunya
  • Gobierno de España
  • Ajuntament de Barcelona
  • Fundació Ramon Arecés

Context científic:

  • Cerca
  • PRBB
  • Universitat Pompeu Fabra - CEI