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Fortuny, J., Kogevinas, M., Zens, M. S., Schned, A., Andrew, A. S., Heaney, J., Kelsey, K. T., Karagas, M. R

Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population-based case control study

BMC.Urol., 2007, 7, 1, , 3, IF: --, PMID: 17692123

ABSTRACT: BACKGROUND: Use of phenacetin and other analgesic and non-steroidal anti-inflammatory drugs (NSAIDs) potentially influences bladder cancer incidence, but epidemiologic evidence is limited. METHODS: We analyzed data from 376 incident bladder cancer cases and 463 controls from a population-based case-control study in New Hampshire on whom regular use of analgesic drugs and NSAIDs was obtained. Odds ratios and 95% confidence intervals were computed using logistic regression with adjustment for potentially confounding factors. Separate models by tumor stage, grade and TP53 status were conducted. RESULTS AND CONCLUSION: We found an elevated odds ratio (OR) associated with reported use of phenacetin-containing medications, especially with longer duration of use (OR >8 years = 3.0, 95% confidence interval (CI) = 1.4-6.5). In contrast, use of paracetamol did not relate overall to risk of bladder cancer. We also found that regular use of any NSAID was associated with a statistically significant decrease in bladder cancer risk (OR = 0.6, 95% CI = 0.4-0.9)., and specifically use of aspirin. Further, the association with NSAID use was largely among invasive, high grade and TP53 positive tumors. While these agents have been investigated in several studies, a number of questions remain regarding the effects of analgesic and NSAID use on risk of bladder cancer

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