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Janson, C., De Marco, R., Accordini, S., Almar, E., Bugiani, M., Carolei, A., Cazzoletti, L., Cerveri, I., Corsico, A., Duran-Tauleria, E., Gislason, D., Gulsvik, A., Jogi, R., Marinoni, A., Martinez-Moratalla, J., Pin, I., Vermeire, P., Jarvis, D

Changes in the use of anti-asthmatic medication in an international cohort

Eur.Respir.J., 2005, 26, 6, 1047, 1055, IF: 3.947, PMID: 16319334

The aim of this study was to describe changes in pharmacotherapy for asthma since the early 1990s in an international cohort of young and middle-aged adults. A total of 28 centres from 14 countries participated in a longitudinal study. The study included 8,829 subjects with a mean follow-up time of 8.7 yrs. Change in the prevalence of use for medication was expressed as absolute net change (95% confidence interval) standardised to a 10-yr period. The use of anti-asthmatics was found to have increased by 3.1% (2.4-3.7%) and the prevalence of symptomatic asthma by 4.0% (3.5-4.5%). In the sample with asthma in both surveys (n = 423), the use of inhaled corticosteroids increased by 12.2% (6.6-17.8%). Despite this, only 17.2% were using inhaled corticosteroids on a daily basis at follow-up. Females with continuous asthma were more likely, compared with males, and smokers with asthma, to have started using inhaled corticosteroids since the first survey. The use of anti-asthmatics has increased in a pattern consistent with current consensus on treatment. However, despite increased use of inhaled corticosteroids, a large majority of subjects with symptomatic asthma do not use this treatment on a daily basis, particularly males and smokers with asthma


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