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Polk, S., Sunyer, J., Munoz-Ortiz, L., Barnes, M., Torrent, M., Figueroa, C., Harris, J., Vall, O., Anto, J. M., Cullinan, P

A Prospective Study of Fel d1 and Der p1 Exposure in Infancy and Childhood Wheezing

Am J Respir Crit Care Med, 2004, 170, 3, 273, 8, IF: 8.123, PMID: 15117746

The impact of domestic exposure to cat allergen (Fel d1) and house dust mite (Der p1) on wheezing from birth to age 4 was investigated in a multi-center prospective birth cohort. 1611 mothers were recruited prior to delivery in Ashford, England and Barcelona and Menorca, Spain. Exposures were gathered via dust sample collection at children\'s home in their first year of life. Families provided complete outcome data (wheezing status in all four years) for 1289 children. Domestic allergen levels varied substantially between centers. 603(47%) children never wheezed during their first four years of life. Der p1 did not correlate with any type of wheezing outcome. Fel d1 significantly increased the risk of wheezing in 3 and 4 year olds in comparison to one year olds. Distinct risk profiles were found for wheezing at different ages. Multivariate analysis revealed an interaction between Fel d1 and maternal asthma among children who wheeze in year 4 (RR= 2.77; 95% CI = 1.19-6.46). Our data support the idea that several patterns of wheezing with different risk profiles exist among young children. The effect of Fel d1 exposure varied according to age and maternal asthma

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