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Sanchez-Mora, C., Ramos-Quiroga, J. A., Bosch, R., Corrales, M., Garcia-Martinez, I., Nogueira, M., Pagerols, M., Palomar, G., Richarte, V., Vidal, R., Arias-Vasquez, A., Bustamante, M., Forns, J., Gross-Lesch, S., Guxens, M., Hinney, A., Hoogman, M., Jacob, C., Jacobsen, K. K., Kan, C., Kiemeney, L., Kittel-Schneider, S., Klein, M., Onnink, M., Rivero, O., Zayats, T., Buitelaar, J., Faraone, S. V., Franke, B., Haavik, J., Johansson, S., Lesch, K. P., Reif, A., Sunyer, J., Bayes, M., Casas, M., Cormand, B., Ribases, M

Case-Control Genome-Wide Association Study of Persistent Attention-Deficit Hyperactivity Disorder Identifies FBXO33 as a Novel Susceptibility Gene for the Disorder

Neuropsychopharmacology, 2015, 40, 4, 915, 26, IF: 7.833, PMID: 25284319

Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with high heritability. At least 30% of patients diagnosed in childhood continue to suffer ADHD during adulthood and genetic risk factors may play an essential role in the persistence of the disorder throughout lifespan. To date, Genome-Wide Association Studies (GWAS) of ADHD have been completed in seven independent datasets, six of which were pediatric samples and one on persistent ADHD using a DNA-pooling strategy, but none of them reported genome-wide significant associations. In an attempt to unravel novel genes for the persistence of ADHD into adulthood, we conducted the first two-stage GWAS in adults with ADHD. The discovery sample included 607 ADHD cases and 584 controls. Top signals were subsequently tested for replication in three independent follow-up samples of 2,104 ADHD patients and 1,901 controls. None of the findings exceeded the genome-wide threshold for significance (PGC<5e-08), but we found evidence for the involvement of the FBXO33 gene in combined ADHD in the discovery sample (P=9.02e-07) and in the joint analysis of both stages (P=9.7e-03). Additional evidence for a FBXO33 role in ADHD was found through gene-wise and pathway enrichment analyses in our genomic study. Risk alleles were associated with lower FBXO33 expression in lymphoblastoid cell lines and with reduced frontal grey matter volume in a sample of 1,300 adult subjects. Our findings point for the first time at the ubiquitination machinery as a new disease mechanism for adult ADHD and establish a rationale for searching for additional risk variants in ubiquitination-related genes.Neuropsychopharmacology accepted article preview online, 06 October 2014. doi:10.1038/npp.2014.267

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