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Vaes, A. W., Garcia-Aymerich, J., Marott, J. L., Benet, M., Groenen, M. T., Schnohr, P., Franssen, F. M., Vestbo, J., Wouters, E. F., Lange, P., Spruit, M. A

Changes in physical activity and all-cause mortality in COPD

Eur.Respir.J., 2014, 44, 5, 1199, 209, IF: 6.355, PMID: 25063247

Little is known about changes in physical activity in subjects with chronic obstructive pulmonary disease (COPD) and its impact on mortality. Therefore, we aimed to study changes in physical activity in subjects with and without COPD and the impact of physical activity on mortality risk. Subjects from the Copenhagen City Heart Study with at least two consecutive examinations were selected. Each examination included a self-administered questionnaire and clinical examination. 1270 COPD subjects and 8734 subjects without COPD (forced expiratory volume in 1 s 67+/-18 and 91+/-15% predicted, respectively) were included. COPD subjects with moderate or high baseline physical activity who reported low physical activity level at follow-up had the highest hazard ratios of mortality (1.73 and 2.35, respectively; both p<0.001). In COPD subjects with low baseline physical activity, no differences were found in survival between unchanged or increased physical activity at follow-up. In addition, subjects without COPD with low physical activity at follow-up had the highest hazard ratio of mortality, irrespective of baseline physical activity level (p


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