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Salas, L. A., Cantor, K. P., Tardon, A., Serra, C., Carrato, A., Garcia-Closas, R., Rothman, N., Malats, N., Silverman, D., Kogevinas, M., Villanueva, C. M.

Biological and Statistical Approaches for Modeling Exposure to Specific Trihalomethanes and Bladder Cancer Risk

Am.J.Epidemiol., 2013, 178, 4, 652, 60, IF: 5.216, PMID: 23648803

Lifetime exposure to trihalomethanes (THM) has been associated with increased risk of bladder cancer. We explored methods of analyzing bladder cancer risk associated with 4 THM (chloroform, bromodichloromethane, dibromochloromethane, and bromoform) as surrogates for disinfection by-product (DBP) mixtures in a case-control study in Spain (1998-2001). Lifetime average concentrations of THM in the households of 686 incident bladder cancer cases and 750 matched hospital-based controls were calculated. Several exposure metrics were modeled through conditional logistic regression, including the following analyses: total THM (mug/L), cytotoxicity-weighted sum of total THM (pmol/L), 4 THM in separate models, 4 THM in 1 model, chloroform and the sum of brominated THM in 1 model, and a principal-components analysis. THM composition, concentrations, and correlations varied between areas. The model for total THM was stable and showed increasing dose-response trends. Models for separate THM provided unstable estimates and inconsistent dose-response relationships. Risk estimation for specific THM is hampered by the varying composition of the mixture, correlation between species, and imprecision of historical estimates. Total THM (mug/L) provided a proxy measure of DBPs that yielded the strongest dose-response relationship with bladder cancer risk. A variety of metrics and statistical approaches should be used to evaluate this association in other settings


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Una iniciativa de:

  • Obra social de la Caixa

  • Hospital Clínic
  • Parc de salut mar
  • Universitat de Barcelona
  • Universitat Pompeu Fabra
  • Generalitat de Catalunya
  • Gobierno de España
  • Ajuntament de Barcelona
  • Fundació Ramon Arecés

Context científic:

  • Cerca
  • PRBB
  • Universitat Pompeu Fabra - CEI