CREAL. Centre de Recerca en Epidemiologia Ambiental


Cercador

Portada > Cercador de publicacions

TornarCercador de publicacions

Castano-Vinyals, G., Talaska, G., Rothman, N., Alguacil, J., Garcia-Closas, M., Dosemeci, M., Cantor, K. P., Malats, N., Real, F. X., Silverman, D., Serra, C., Carrato, A., Tardon, A., Garcia-Closas, R., Kogevinas, M., Vermeulen, R

Bulky DNA adduct formation and risk of bladder cancer

Cancer Epidemiol.Biomarkers Prev., 2007, 16, 10, 2155, 2159, IF: 4.642, PMID: 17932365

Exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with risk of bladder cancer and with increased bulky DNA adduct levels in several studies, mainly in smokers. We investigated the relation between bulky PAH-DNA adducts in peripheral blood mononuclear cells and bladder cancer in nonsmoking subjects from a large hospital-based case-control study in Spain. Additionally, we examined the association between DNA adduct formation and several air pollution proxies. The study comprised 76 nonsmoking cases and 76 individually matched controls by sex, region of residence, age, and smoking status (never, former). To maximize the relevance of the DNA adduct measurement as a proxy of PAH exposure, subjects selected had not changed residence, occupation, and major lifestyle factors during the last 10 years. Bulky DNA adducts were measured using the (32)P-postlabeling technique, nuclease P1 treatment. The percentage of detectable adducts was higher in controls (41%) than in cases (32%) with an odds ratio of 0.75 (95% confidence interval, 0.36-1.58). In an analysis limited to controls, a higher percentage of DNA adducts was found among those whose last residence was in a big city (50%) compared with those living in villages (19%; P = 0.04). No consistent associations were found for other markers of air pollution. In this study, among nonsmokers with stable environmental and lifestyle factors, bulky DNA adducts were not associated with bladder cancer risk. Results do not support an association of bladder cancer risk with low-level exposure to PAHs as measured through the formation of bulky DNA adducts in peripheral mononuclear cells. (Cancer Epidemiol Biomarkers Prev 2007;16(10):2155-9)

ONCOLOGY, PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH


Imatge ilustrativa


ISGlobal - Campus Mar · Doctor Aiguader, 88 · E-08003 Barcelona · Tel +34 93 214 73 00 · Fax +34 93 214 73 02 · e-mail: RSS

Una iniciativa de:


Context científic: