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Nunez, B., Sauleda, J., Anto, J. M., Julia, M. R., Orozco, M., Monso, E., Noguera, A., Gomez, F. P., Garcia-Aymerich, J., Agusti, A

Anti-Tissue Antibodies are Related to Lung Function in Chronic Obstructive Pulmonary Disease

Am.J.Respir.Crit Care Med., 2011, 183, 8, 1025, 31, IF: 10.689, PMID: 21097696

Background. Chronic obstructive pulmonary disease (COPD) is a multi-component disease. Auto-immunity can contribute to the pathogenesis of COPD. This study investigates the prevalence of circulating antinuclear (ANA) and antitissue (AT) antibodies, two common markers of autoimmunity, in COPD and their relationship with several components of the disease. Methods. We determined lung function, the serum titers of ANA and AT by immunofluorescence and the serum levels of C - reactive protein (CRP) by high sensitivity nephelometry in 328 patients with clinically stable COPD and in 67 healthy controls recruited in the PAC-COPD study. Multiple linear and logistic regression analysis were used to analyze results. Results. The prevalence of abnormal ANA and AT titers was 34% and 26% in patients and 3% and 6% in controls, respectively. Levels of AT >/= 1:320 were seen in 21% of COPD patients and were independently associated with the severity of airflow limitation and gas transfer impairment (p<0.05). Neither ANA or AT titers were related to the body mass index, current smoking status, use of inhaled steroids, the Charlson index or serum CRP values. Conclusions. Between a quarter and a third of patients with clinically stable COPD present abnormal titers of circulating ANA and AT. The observed relationship between AT and lung function supports a role for auto-immunity in the pathogenesis of COPD


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