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Schembari, A., de Hoogh, K., Pedersen, M., Dadvand, P., Martinez, D., Hoek, G., Petherick, E. S., Wright, J., Nieuwenhuijsen, M. J.

Ambient Air Pollution and Newborn Size and Adiposity at Birth: Differences by Maternal Ethnicity (the Born in Bradford Study Cohort)

Environ Health Perspect., 2015, 123, 11, 1208, 15, IF: 7.029, PMID: 25978617

BACKGROUND: Exposure to ambient air pollution has been associated with reduced newborn's size, however the modifying effect of maternal ethnicity remains little explored among South Asians. OBJECTIVES: To investigate ethnic differences in the association between ambient air pollution and newborn's size. METHOD: Pregnant women were recruited between 2007 and 2010 for the Born in Bradford cohort study, in England. Exposures to particulate matter (PM10, PM2.5), PM2.5 absorbance and nitrogen oxides (NOx, NO2) were estimated using land-use regressions models. Effect modification by maternal ethnicity ("White British" or "Pakistani origin", self-reported) on the associations of air pollution and birth weight, head circumference, and triceps and subscapular skinfold thickness was evaluated using multivariate linear regression models. RESULTS: A 5-mug/m3 increase in mean third trimester PM2.5 was associated with significantly lower birth weight and smaller head circumference in children of White British mothers (-43g; 95% CI: -76, -10 and -0.28cm; 95% CI: -0.39, -0.17, respectively), but not in children of Pakistani origin (9g; 95% CI: -17, 35 and -0.08cm; 95% CI: -0.17, 0.01, respectively) (Pint= 0.03 and <0.001). In contrast, PM2.5 was associated with significantly larger triceps and subscapular skinfold thicknesses in children of Pakistani origin (0.17mm; 95% CI: 0.08, 0.25 and 0.21mm; 95% CI: 0.12, 0.29, respectively), but not in White British children (-0.02mm; 95% CI: -0.14, 0.01 and 0.06mm 95% CI: -0.06, 0.18, respectively) (Pint= 0.06 and 0.11). Patterns of associations for PM10 and PM2.5 absorbance according to ethnicity were similar to PM2.5, while associations of the outcomes with NO2 and NOx were mostly non-significant in both ethnic groups. CONCLUSIONS: Our results suggest that associations of ambient PM exposures with newborn size and adiposity differ between White British and Pakistani origin infants

ENVIRONMENTAL SCIENCES, PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, TOXICOLOGY


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