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Dennis, K. K., Marder, E., Balshaw, D. M., Cui, Y., Lynes, M. A., Patti, G. J., Rappaport, S. M., Shaughnessy, D. T., Vrijheid, M., Barr, D. B

Biomonitoring in the Era of the Exposome

Environ.Health Perspect., 2016, PMID: 27385067

BACKGROUND: The term "exposome" was coined in 2005 to underscore the importance of the environment to human health and bring research efforts in line with those on the human genome. The ability to characterize environmental exposures through biomonitoring is key to exposome research efforts. OBJECTIVES: Our objective was to describe why traditional and non-traditional (exposomic) biomonitoring are both critical in studies aiming to capture the exposome and make recommendations on how to transition exposure research toward exposomic approaches. We describe the biomonitoring needs of exposome research and approaches and recommendations that will help fill the gaps in the current science. DISCUSSION: Traditional and exposomic biomonitoring approaches have key advantages and disadvantages for assessing exposure. Exposomic approaches differ from traditional biomonitoring methods in that they can include all exposures of potential health significance, whether from endogenous or exogenous sources. Issues of sample availability and quality, identification of unknown analytes, capture of non-persistent chemicals, integration of methods and statistical assessment of increasingly complex datasets remain as challenges that must continue to be addressed. CONCLUSIONS: To understand the complexity of exposures faced across the lifespan, traditional and nontraditional biomonitoring methods should both be used. Through hybrid approaches and integration of emerging techniques, biomonitoring strategies can be maximized in research to define the exposome

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