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Hoyer, B. B., Ramlau-Hansen, C. H., Vrijheid, M., Valvi, D., Pedersen, H. S., Zviezdai, V., Jonsson, B. A., Lindh, C. H., Bonde, J. P., Toft, G

Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances

Environ.Health Perspect., 2015, 123, 8, 841, 6, IF: 7.029, PMID: 25809098

BACKGROUND: In some animal studies, perfluorinated alkyl substances are suggested to induce weight gain. Human epidemiological studies investigating these associations are sparse. OBJECTIVE: To examine pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and the prevalence of offspring overweight (> 1 standard deviation) and waist-to-height ratio (WHtR) > 0.5 at five to nine years of age. METHODS: Sera from 1,022 pregnant women enrolled in the INUENDO cohort (2002-2004) from Greenland and Kharkiv (Ukraine) were analysed for PFOA and PFOS using liquid chromatography-tandem-mass-spectrometry. Relative risks (RR) of being overweight and having WHtR > 0.5 in relation to continuous and categorised (tertiles) PFOA and PFOS were calculated at follow-up (2010-2012) using generalised linear models. RESULTS: Pooled PFOA median (range) was 1.3 (0.2-5.1) and PFOS median (range) was 10.8 (0.8-73.0) ng/mL. For each natural logarithm-unit (ln-unit) increase of pregnancy PFOA, the adjusted RR of offspring overweight was 1.11 (95% confidence interval (CI): 0.82, 1.53) in Greenlandic children. In Ukrainian children, the adjusted RR of offspring overweight was 1.02 (95% CI: 0.72, 1.44) for each ln-unit increase of pregnancy PFOA. Prenatal exposure to PFOS was not associated with overweight in country-specific or pooled analysis. The adjusted RR of having WHtR > 0.5 for each ln-unit increase of prenatal exposure to PFOA was 1.30 (95% CI: 0.97, 1.74) in the pooled analysis. For one ln-unit increase of prenatal exposure to PFOS, the adjusted RR of having a WHtR > 0.5 was 1.38 (95% CI: 1.05, 1.82) in the pooled analysis. CONCLUSIONS: The results indicate that prenatal PFOA and PFOS exposure may be associated with child waist-to-height ratio > 0.5. Prenatal PFOA and PFOS exposure were not associated with overweight


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