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Dimakopoulou, K., Samoli, E., Beelen, R., Stafoggia, M., Jovanovic, Andersen Z., Hoffmann, B., Fischer, P., Nieuwenhuijsen, M., Vineis, P., Xun, W., Hoek, G., Raaschou-Nielsen, O., Oudin, A., Forsberg, B., Modig, L., Jousilahti, P., Lanki, T., Turunen, A., Oftedal, B., Nafstad, P., Schwarze, P. E., Penell, J., Fratiglioni, L., Andersson, N., Pedersen, N., Korek, M., de Faire, U., Thorup, Eriksen K., Tjonneland, A., Becker, T., Wang, M., Bueno-de-Mesquita, B., Tsai, M. Y., Eeftens, M., Peeters, P. H., Meliefste, K., Marcon, A., Kramer, U., Kuhlbusch, T. A., Vossoughi, M., Key, T., de Hoogh, K., Hampel, R., Peters, A., Heinrich, J., Weinmayr, G., Concin, H., Nagel, G., Ineichen, A., Jacquemin, B., Stempfelet, M., Vilier, A., Ricceri, F., Sacerdote, C., Pedeli, X., Katsoulis, M., Trichopoulou, A., Brunekreef, B., Katsouyanni, K

Air Pollution and Non-Malignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project

Am.J.Respir.Crit Care Med., 2014, 189, 6, 684, 96, IF: 11.041, PMID: 24521254

Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic related air pollution is associated with reduced survival. However, the effects on non-malignant respiratory mortality are less studied and those reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution and non-malignant respiratory mortality in 16 cohorts with individual level data within the multi center European Study of Cohorts for Air Pollution Effects (ESCAPE). Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. Measurements: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases, following a standardized procedure within ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using meta-analyses. Main Results: We found no significant associations between air pollution exposure and non-malignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. Conclusions: In this study of 16 cohorts there was no association between air pollution exposure and non malignant respiratory mortality


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