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Meta-analysis of the Air Pollution and Pregnancy-Induced Hypertensive Disorders Relationship

CREAL researchers led a systematic review and meta-analysis published in Hypertension

Wednesday, June 25th, 2014

Meta-analysis of the Air Pollution and Pregnancy-Induced Hypertensive Disorders Relationship

Pregnancy-induced hypertensive disorders can lead to maternal and perinatal (period before or after the baby is born) morbidity and mortality. However, the cause of these conditions is not well understood. Therefore, the researchers, led by Marie Pedersen, researcher at CREAL, an ISGlobal research center, have systematically reviewed and performed a meta-analysis of epidemiological studies investigating the association between exposure to ambient air pollution and pregnancy-induced hypertensive disorders including gestational hypertension and preeclampsia.

Most studies reported that air pollution increased risk for pregnancy-induced hypertensive disorders. The researchers observed a significant heterogeneity in meta-analysis, which included 16 studies reporting on gestational hypertension and preeclampsia as separate or combined outcomes. “However, there was more homogeneity in findings of the 10 studies reporting solely on preeclampsia. Meta-analyses showed increased risks of hypertensive disorders in pregnancy for all pollutants except carbon monoxide (CO). Our results suggest that exposure to air pollution increases the risk of pregnancy-induced hypertensive disorders”, explains Pedersen.

“We searched in electronic databases for studies reporting associations between ambient air pollution and pregnancy-induced hypertensive disorders published between December 2009 and December 2013”, says Pedersen. Combined risk estimates were calculated using random-effect models for each exposure that had been examined in four or more studies. Heterogeneity and publication bias were evaluated. A total of 17 articles met the inclusion criteria of air pollutants, such as nitrogen oxides (NO2, NOX), particulate matter (PM10, PM2.5), carbon monoxide (CO) and ozone (O3); proximity to major roads, and traffic density.

Reference of the study:

Ambient Air Pollution and Pregnancy-Induced Hypertensive Disorders: A Systematic Review and Meta-Analysis. Marie Pedersen, Leslie Stayner, Rémy Slama, Mette Sørensen, Francesc Figueras, Mark J. Nieuwenhuijsen, Ole Raaschou-Nielsen, Payam Dadvand. Hypertension 2014.


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