Air pollution is the first preventable environmental risk factor in the world and in Europe. Its health impact is mainly due to its effect on aging via oxidative stress and low-grade systemic inflammation. The short term and long term effects of air pollution on respiratory, cardio-vascular and neurological effects are going to be reviewed as well as the health benefits following air pollution interventions. Current cohort studies conducted at CREAL in adults on carotid thickness and in children on reproductive and neurodevelopmental outcomes are going to be presented as well as a large study on brain impairment in school children. Its potential remediation is going to be discussed.